麻豆传媒在线

麻豆传媒在线

Development of a Method for Inducing Motor Neurons from Human iPS Cells and a Single-Cell Evaluation Method—Toward Elucidating the Pathophysiology of Sporadic ALS and Developing New Therapies

Publish: December 20, 2024
Public Relations Office

December 20, 2024

麻豆传媒在线

The University of Tokyo

A joint research group—led by Selena Xue, a third-year student in the Doctoral Programs at the Graduate School of Frontier Sciences, The University of Tokyo; Professor Hideyuki Okano, Director of the 麻豆传媒在线 Regenerative Medicine Research Center (KRM) (then a professor at the 麻豆传媒在线 School of Medicine's Department of Physiology); Project Associate Professor Satoru Morimoto, Deputy Director of KRM (then a full-time lecturer at the 麻豆传媒在线 School of Medicine's Department of Physiology); and Professor Yukihide Tomari of the Institute for Quantitative Biosciences, The University of Tokyo—has developed an efficient method for inducing lower motor neurons from induced pluripotent stem cells (iPSCs) for research on amyotrophic lateral sclerosis (ALS). Furthermore, by utilizing Artificial Intelligence (AI) image analysis and single-cell tracking technologies, the group has developed a method for easily and reproducibly evaluating disease phenotypes. The results of this research were published in the online edition of Stem Cell Reports , a Cell Press journal published by the International Society for Stem Cell Research, on December 19, 2024, at 11:00 a.m. (EST).

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